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Date: 28.11.2012
From: Gillian

Subject: Methotrexate Initially Causing Excessive Tiredness

I started Methotrexate two weeks ago and last few days I have experienced extremem tiredness. Going to bed early, dropping off straight away and struggling to stay awake during the day. I rang Rheumatology Help Line at local hospital today and they have said to stop taking the metho for two weeks and then restart again on the third week. Has anyone else experienced this as well?
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Date: 28.11.2012
From: Colin

Subject: Re: Methotrexate Initially Causing Excessive Tiredness

hi Gillian

when I first had RA was having saame problems even before starting Mtx which been taking over 14 years now .
what worked for me was mild antidepressant like St John Wort but you have to be careful with that & changed to something else

would talk to your GP or rhummy nurse
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Date: 28.11.2012
From: rhona

Subject: Re: Methotrexate Initially Causing Excessive Tiredness

Hi Gillian, I have rheumatoid arthritis and i know that can cause extreme tiredness. I am also on mtx. but not sure if that is a side effect or not from it.
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Date: 28.11.2012
From: Gillian

Subject: Re: Methotrexate Initially Causing Excessive Tiredness

Thank you for your replies. I have had RA diagnosed for two years almost but I have never experienced so much tiredness before I started methotrexate two weeks ago. I just wish all this RA and fibro would go away and let me live a better quality of life.
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Date: 01.12.2012
From: Anne

Subject: Re: Methotrexate Initially Causing Excessive Tiredness

Hi Gillian,

I was diagnosed with RA in Aug this year and put on Methotrexete, blood tests every 2 weeks now down to one per month, i work full time and would advise to take at weekend as you can initially feel tired,the good news is pain free now, bear with this medication for a few months to see if it suits you,the best advise i can give anyone is do not read too much into the side effects as this drug can work for some with no or very little side effects, its just a case of finding the correct drug that suits you, good luck
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Date: 01.12.2012
From: Gillian

Subject: Re: Methotrexate Initially Causing Excessive Tiredness

Thank you for your reply Anne. What dose do you take and what day? Do you take folic acid as well? Its hard working full time isnt it. Do you take Sulfasalazine as well. I have been taking that for about a year now.
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Date: 02.12.2012
From: sue d

Subject: Re: Methotrexate Initially Causing Excessive Tiredness

Hi Gillian,taken methotrexate for 6 years now also work full time and finding its getting more difficult also take folic acid for 6 days a week to cut down any side effects that you can get.was advised to take it on day off also and only side effect i have had is feeling sick when i first started taking it and on each occasion the dosage went up but it soon passed,as for feeling tired all the time i think with me its part of the ra and lack of sleep some nights due to pain during night.hope you get sorted soon with medication it does take a while to start working if i remember right it took 3months before i felt the benefit but it was worth it.
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Date: 09.12.2012
From: Lorraine

Subject: Re: Methotrexate Initially Causing Excessive Tiredness

Hi i have had my MTX increased to 6 tabs instead of 4 omg what a weekend i have had feeling sick and being sick Friday and Saturday , slept for 10 hours yesterday and still tired all day phoning Rhumy Nurse i can't cope with it
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Date: 03.03.2013
From: lyuzita

Subject: Re: Methotrexate Initially Causing Excessive Tiredness

I can hepl tray my method
http://sheringhamski.weebly.com/
http://www.facebook.com/matushka.zemlja
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Date: 06.03.2013
From: Kim

Subject: Re: Methotrexate Initially Causing Excessive Tiredness

Hi, I've been on methotrexate since oct last year, I started on 5mg and am now up to 20mg and taking it by injection. It knocks me out! I was taking it on a Monday but this week am taking it Friday so as not to effect my working week. It usually effects me the second day after taking it and lasts for 2-3 days.
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Date: 19.03.2013
From: Georgina

Subject: Re: Methotrexate Initially Causing Excessive Tiredness

Can I please ask how you find the drug Sulfasalazine works for you..I have had RA for over 6 years now. I take Metho. Folic acid (this helps with mouth ulcers and burned mouth syndrome) and pain relief. I am beginning to feel I get very little relief anymore from any of my drugs.
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Date: 23.03.2013
From: Emma

Subject: Re: Methotrexate Initially Causing Excessive Tiredness

Hi everyone, I have been on methotraxate for 2 yrs they took me off it for 3 weeks I started flaring so put back on it with my humira. Since going back on it not sleeping at night and burning up like I have a fever has anyone else suffered with this. Any advice would be appreciated, hope eveyone is as well as they can be. Em x
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