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Date: 28.08.2011
From: Rainbow444

Subject: Methotrexate not working

I have been talking Methotrexate for 12 months, dosage is now 25mgs. It doesn't seem to working as symptons are springing up in new addition areas. What will happen now? GP thinks I need a change of meds. Ive only been diagnosed 12months and Methotrexate was my first try of DMARDs. What drug can they try now?
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Date: 29.08.2011
From: joanna

Subject: Re: Methotrexate not working

why did they put you on Methotrexate and not try sulphasalazine first? Perhaps they will try that next, good luck x
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Date: 30.08.2011
From: dilizjo

Subject: Re: Methotrexate not working

Hiya:) I too was put on Meth straight away after being diagnosed 4 months ago, I know they can take up to 6 months to show any improvement but to be honest if anything I am feeling much worse:( I have been upped to 15mg a week now from the original 10mg) I haven't been offered any other options. Think I will ahve a chat with my Rheummy nurse next week when I go.
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Date: 30.08.2011
From: davina

Subject: Re: Methotrexate not working

hi rainbow i was put on meth stright away too but syptoms didn't carm so i was put on to plaquenil and enbrel anti-tnf.

you proberly will be given an additional med to hopefully work with the methotrexate.

you could be given plaquenil or sulphasazine as joanne said.
hope this helps take care. x
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Date: 01.09.2011
From: Rachel

Subject: Re: Methotrexate not working

Hi Rainbow, I'm having the same problem. Diagnosed a year ago with RA, blood results no lower and started on sulph in October last year then Methotrexate 15mg in December. Having more problems than a year ago, with pain levels increasing & in more areas. Counting the days to my next rheumy appointment. I can understand the frustration! x
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Date: 02.09.2011
From: Colin

Subject: Re: Methotrexate not working

Hi

I take both Methotrexate and sulphasalazine + you should also have a NSAIDs , you need to see rheumatology doctor & get it under control & maybe some Anti TNF drugs

dont suffer go see someone , they got drugs which will get it under control
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Date: 04.09.2011
From: mads

Subject: Re: Methotrexate not working

Hi Rainbow - metx worked a little for me but i had side effects and was taken off and am still in limbo waiting for my next dmard - 2 months now, i have had a steroid but it has just taken the edge off. They are going to put me on plaquenil but had to get my eyes tested first, hopefully they will add something additional as well. Also didn't get a next appointment with rheum. consultant ahhh Fed up - I have every sympathy with your frustration.
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