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Date: 17.06.2010
From: Teresa

Subject: How do people get on with Methotrexate?

Hi everyone!
Okay, so after taking Sulfasalazine for PA it has had no affect and if anything things are getting worse! I have been told I am to start taking Methotrexate. I was hoping people who take this drug could tell me how it affects them? Good and bad!! (hopefully it will be mostly good though!) And if their joints have improved since taking it?
Take care
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Date: 17.06.2010
From: Angela

Subject: Re: How do people get on with Methotrexate?

Hi Teresa,I have RA, I took sulfasalizine for 7 months with little change. The rhummy then put me on a combination of sulfa and methotrexate, and within a month I felt a change less stiff less joint discomfort, been on it for 7 months now.
I have un beknown to the rhummy stopped the sulfa and carried on with the mtx only though, and still feel pretty good.
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Date: 18.06.2010
From: Sally

Subject: Re: How do people get on with Methotrexate?

hi Teresa, I've been on 7.5 mg since January. It's helping to some degree but not totally. Also on prednisilone. I got a few side effects to begin with but they have worn off a bit - nausea and tiredness both not really a problem at the moment. Might be different when I go up on MTX!
tc
xx
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Date: 18.06.2010
From: Verity

Subject: Re: How do people get on with Methotrexate?

Hey Teresa,
I had results when I first started MTX but it just makes me sick now! I take 25mg every week (with etanercept).Makes me feel eally run down and sick with tummy upsets etc for a few days after. All immuno suprressants do the same though unfortunately!
Works well with the etanercept though : ) xx
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Date: 21.06.2010
From: Abbie

Subject: Re: How do people get on with Methotrexate?

Hi there! I have had mixed results on mtx. I was diagnosed with PA last August and put on 10mg and Only side effects were extreme fatigue and next day headache. By october was worse so went up to 12.5 for one month then up to 15mg. On 12.5mg slight nause that day and day after. On 15mg nause and vomitting all day every day and mouth sores. After three weeks of this I split the dose to half weds and half sun and nausea and vomitting went. Increased my folic acid from 15mg day after mtx to 5mg daily for mouth sores these still came and went but not as bad. In Jan I was no better with my PA, worse If anything so went on to injections, 15mg once a week. Quite pleased coz no sickness returned but still getting mouth sores but not as much. 9wks ago saw Rheumy and coz still getting nowhere He said go to 17.5mg for 4wks then up to 20mg and when go back after 12wks He would've found out from neuro If can start Infliximab/Remicade. Well while new shots were being organized mouth sores got real bad and one got infected. Coz of this increases were pulled and I had to go without shots for 2wks. This was quite telling because where I thought mtx was doing nothing, while no mtx got REALLY bad worse than ever. Rheumy said disease had obviously got alot worse but mtx was keeping it at original level. Very frustated though because when I got back in 3wks i'll be no further forward and will be just a week away from when it all started. Still getting mouth sores. Who knows in 3wks maybe the Remicade will start. I hope this has helped without putting you right off. Go well X
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Date: 21.06.2010
From: Sally

Subject: Re: How do people get on with Methotrexate?

Hi Abbie, you have been on a roller coaster ride from the sound of it. I just wanted to ask you what you mean by mouth sores. I have had ulcers occasionally but last week the corner of my mouth got very sore and painful. Is that what you are talking about? Am going up to 10mg today as joints really bad and seeing rheumy on Wed. How long did it take for it to make an improvement if you increased mtx?
tc
xx
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Date: 21.06.2010
From: Teresa

Subject: Re: How do people get on with Methotrexate?

Hi everyone, thank you for all your info on how you get on with Methotrexate.
I have to admit im slightly worried about taking it.. but then I was worried about the sulfasalazine too. And despite having an allergic reaction to the sulfasalazine I was not that worried about it! I was more miffed at having to go to the supermarket to buy pack lunch stuff for my daughter with my face so swollen I looked like the elephant man!
Does anyone know if once you have started taking any of the DMARDS and then you stop your condition can get worse? Because since i have stopped the sulfasalazine and am waiting to start the methotrexate my PA has never been so bad!
Take care all xx
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Date: 26.06.2010
From: Abbie

Subject: Re: How do people get on with Methotrexate?

@Sally, my mouth sores start as very sore ulcers then turn black/brown and slightly puss filled. I've not had any probs with the corner of my mouth. @Teresa. I had to stop my mtx shots for two weeks coz of infection and my PA seemed worse than ever.
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Date: 27.06.2010
From: sally

Subject: Re: How do people get on with Methotrexate?

Sounds horrible Abbie! Saw rheumy last week and he thinks my prob is the steroids. Got to have mtx injections soon as it's not working for me. Been in a lot of pain recently but back on the pred so am feeling a bit better this weekend.
xx
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Date: 01.07.2010
From: jill

Subject: Re: How do people get on with Methotrexate?

im going on MTX Injections...cant wait, then will help my Gut....
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Date: 02.07.2010
From: Abbie

Subject: Re: How do people get on with Methotrexate?

Wow Jill, with having tummy probs can't believe you're not on shots already. Hopefully you will find a difference I sure did. X
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