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Date: 02.12.2016
From: Sean

Subject: AUTOIMMUNE DISEASE STARTS IN THE GUT - BBC Today

This was in on the BBC website today - thought I would share here -

Parkinson's disease 'may start in gut'

>>>> http://www.bbc.com/news/health-38173287

Not sure who will be interested but I have posted here a few times before about the role of gut bacteria in autoimmune disease.

For me - It has been nearly 2 years now since my last real Ankylosing Spondylitis flare.

The best way to describe is that at times I go from nearly 100% better to felling that my immune system teeters on the edge. I am now able to trace the reason for any slight relapse.

My AS is 100% gut related - all my 'nearly' flare ups have been due to excess sugars in my diet. And this is despite always being 100% corn and gluten free.

Autoimmune disease isn't about "this food" or "that food" or "this bacteria" or another bacteria.

It is the incorrect "presentation" of a Protein to the immune system. When a protein is presented it is tagged to generate a specific immune response.

Gut bacteria and mineral status inform the immune system during the presentation of proteins to the immune system.

...and gut bacteria are impacted by what we eat and drink.... and gut bacteria will only "leak" in to the blood stream in the first place due to certain conditions and when we eat certain foods.

I'm sure we will find that all AI diseases start the same way - whether they can be stopped is another question!

BTW I'm on TWITTER now over a year connecting with loads of diet researchers all over the world -

@Treat_Me_Gently
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Date: 02.12.2016
From: Sean

Subject: Re: AUTOIMMUNE DISEASE STARTS IN THE GUT - BBC Today

A related link from the above to Rheumatoid Arthritis is here in this recent medical study from 2013 -

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131749/

For me the 2 culprits for RA are -

> Proteus Mirabilis
> E Coli


I believe from research that the gut bacteria that initiates RA is likely to be Proteus Mirabilis - but this would result in sero-negative RA for most people.

E Coli reaction I believe to be related to sero-positive RA - where specific parts of the E-Coli DNA have been mis-recognised and incorrectly presented to the immune system


Please note many bacteria are not bad - those above are normal residents of a healthy gut.

Our issues arise when a DYSBIOSIS/ or GUT DAMAGE causes a protein 'foreign body' (either a fragment of bacteria or food) to be incorrectly presented to the immune system.

The NCBI paper linked above discuss 2 roles for bacteria

> 1 - As the triggering antigen that has been incorrectly presented (like the 2 above)

> 2 - As a modifier of other proteins (as in gum bacteria)

Modification of a protein is a change to the DNA code - altering a fragment of the protein - this then creates novel DNA sequences that the immune system struggles to know how to tag.

Some of you on here will remember a chap that posted here a few years back on the Seignalet diet - and cooking food at less than 105 degrees C. Based on my continued study - there is merit in this as excessive heating of some foods causes protein changes too - no in themselves bad, but for a person whose immune system is already struggling to differentiate 1 protein from another - it is a further challenge.


What causes Gut Damage? - NSAID and grains like wheat in many people.
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Date: 02.12.2016
From: Colin W

Subject: Re: AUTOIMMUNE DISEASE STARTS IN THE GUT - BBC Today

Sean , I would question the results & they need a lot more testing , age related Parkinson's goes with other conditions like strokes , transient ischemic attack (TIA), epileptic seizures & some forms of dementia

as for RA , we know there is a link between the stomach/gut but think they still dont know what is causing the problem , the use of antibiotics works in lowering the immune system & helps even if its done through intravenous drip so dont think its anything to do with infection like a lot want to believe
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Date: 02.12.2016
From: Sean

Subject: Re: AUTOIMMUNE DISEASE STARTS IN THE GUT - BBC Today

There is also much too much noise for decades of research in to the role of food proteins in disease - again tied to gut dysfunction. Still going on today. Most AI diseases start in the gut.

Like this one - where you see that even dietary proteins from wheat "may" be involved in MS. From other research I believe this to be the case

https://www.ncbi.nlm.nih.gov/pubmed/15355487


IF YOU RESEARCH CELIAC YOU WILL SEE THAT IT HAS MULTIPLE DISEASE OUTCOMES - people are naive to think if a small fragment of wheat protein can cause these that other "proteins" that "clash" with DNA in our own bodies will not also cause disease.

CELIAC (caused by a tiny protein fragment of grain) can cause....

> GUT
> SKIN (Dermatitis)
> BRAIN (Ataxia and even dementia!)
> ARTHRITIS


I have a friend and a family member of my wife with MS - both started at younger age late 40's

I don't think it is just infection - I did not say that. We have discussed before on here - and you believe that 'infection' hypothesis is an old dis-proven theory.

Yes it is an old theory - but one that was on the right track. But was usurped with drug treatments that switch off the disease instead of trying to identify and tackle the causes.

It is a multi-factorial break down of immune tolerance to self - initiated by one or many of these in conjunction -

> Infection
> Gut Bacteria Balance issue (dysbiosis) - caused by heavy metals
> Gut Bacteria Balance issue (dysbiosis) - caused by years of bad diet excessive carbohydrate / sugars
> Gut damage due to diet or medication (specifically NSAIDs)
> The presence of toxins during antigen presentation
> Food Allergy

Multi-factorial means that it not infection per-say - it is the bodies failure to deal with the after-effects of infection.

I also use the term infection loosely - as any foreign protein presented to the immune system requires an immune response. So antigen is a better term that infection.

Not sure if you are aware - but 'germ free mice' in experiments do not get RA or MS - they are bred with a sterile gut. When specific bacteria are reintroduced, the Mice (that also carry the genes to develop RA /MS) get the disease.

The other conditions you mentioned - I believe are part for the same mechanism. TIA and Epilepsy often associated with gut dysfunction in medical literature.
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Date: 14.12.2016
From: Sean

Subject: Re: AUTOIMMUNE DISEASE STARTS IN THE GUT - BBC Today

I read 2 new medical papers tonight - and discussed the subject with a top surgeon

1) 54 obese patients with active RA underwent bariatric surgery. Within 3.2 years - 74% of them were in remission.

2) an amazing analysis of how resident gut bacteria influence autoimmune disease

http://journal.frontiersin.org/article/10.3389/fmicb.2016.00084/full?utm_source=twitterfeed&utm_medium=twitter

Surgeon suggests that bariatric surgery vastly alter gut Microbiome !
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Date: 01.02.2017
From: andyswarbs

Subject: Re: AUTOIMMUNE DISEASE STARTS IN THE GUT - BBC Today

Sean, I think you are right on a lot of points...

ColinW, more testing is definitely needed. In the meantime if some people can find remission using an elimination diet that has a great balance of nutrients throughout then surely that's a worthwhile approach to consider.
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