Subject: New Medical Article - The human microbiome and juvenile idiopathic arthritis
I saw this article from someone I follow to Twitter - http://ped-rheum.biomedcentral.com/articles/10.1186/s12969-016-0114-4 The link to balance of gut bacteria stood out for me, especially the reference to B. Fragilis - as too many carbohydrates flare me too. The article says that B. Fragilis is important in ensuring that T-REGS are instigated when any antigen is presented to the immune system. I checked out a few bits online.. We have this - https://en.wikipedia.org/wiki/Regulatory_T_cell T-REGS "are a subpopulation of T cells which modulate the immune system, maintain tolerance to self-antigens" And we have this -
https://en.wikipedia.org/wiki/Bacteroides "Studies indicate that long-term diet is strongly associated with the gut microbiome composition - those who eat plenty of protein and animal fats have predominantly Bacteroides bacteria, while for those who consume more carbohydrates the Prevotella species dominate" It is clear that a rise and fall of flare activity can be due to gut bacteria composition and maintenance of gut barrier - and that a strict diet that limits carbohydrate, eliminates gluten completely - along with targeted po-biotics / fermented foods (and perhaps anti-biotics that target specific strains) will regulate gut meditated immune response.
As for antibiotics - it looks like they try. In this study they used "metronidazole" which does target Prevotella Copri - but it also kills Bacteroides Fragilis. Therefore killing friend and foe at the same time! http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1004741/
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