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Date: 02.02.2016
From: Jane

Subject: HLA B27

Could any one tell me if you can have psoriatic or reactive arthritis, but test negative for HLA B27 ?
Many thanks.
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Date: 02.02.2016
From: Sean

Subject: Re: HLA B27

Hi Jane

I think HLA B27 has much stronger link to Ankylosing Spondylitis

With PsA and ReA it is about 50 to 60 percent but with AS it is approx 90 to 95 percent!

I am one of the 5 to 10 percent without HLA B27 that have AS.

So there is at least 40 to 50 % of PsA and ReA arthritis sufferers without the exact gene.

They tend to hedge with undifferentiated or non-specific if they can't see the exact tell tell damage or the genes test comes up negative - but my Father had AS and is HLA B27 positive and I am fully aware of the symptoms. They try and make diagnosis exactly to pigeon-hole us.

There are genes that are not tested for also like HLA B39 - which also has links to inflammatory arthritis - so I dont know if I have that :)

http://www.ncbi.nlm.nih.gov/pubmed/3735281
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Date: 02.02.2016
From: Jane

Subject: Re: HLA B27

Sean ,

Thank you so much for replying , I wasn't aware

that HLA B27 is only present in 50 to 60 % of

people with PsA & ReA.
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Date: 02.02.2016
From: Sean

Subject: Re: HLA B27

Hi Jane

I found different figures :(

Seems to vary based on different studies - this one said 72% negative and those that were positive were mostly men

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699907/
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