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Date: 16.11.2015
From: Sean

Subject: Intestinal Permeability - again.. not just arthritis

My wife has been sporadically eating Gluten free - and today admitted that she has noticed hot flushes happen each time she has it! She previous was diagnosed with some issues for PCOS a number of years ago.

I had a strong hunch that Estrogen balance was involved with both previous and recent issues - and did some research to see if there was any studies out there.

We know that a chemical called Zonulin is released in all people in response to gluten proteins.

Just found this searching for estrogen - http://www.ncbi.nlm.nih.gov/pubmed/25336505

Serum zonulin is elevated in women with polycystic ovary syndrome and correlates with insulin resistance and severity of an-ovulation.

"Serum zonulin, a biomarker for gut permeability, is increased in PCOS women and correlates with insulin resistance and severity of menstrual disorders. It suggests that alterations in gut permeability may play a role in the pathophysiology of PCOS, and serum zonulin might be used as a bio-marker for both risk stratification and therapeutic outcomes in PCOS women."


I am also sure that this also ties in long term with Osteoarthritis and bone resorption.
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