Subject: Back to the bacteria - diabetes type 1 and RA
There was the usual fanfare splash in the Daily Express on Friday that BCG TB jabs may 'cure' type 1 diabetes and stop the destruction of the Pancreas.
Following the BCG idea - a few minutes googling found me this....
It seems though TB has been studied a lot for molecular mimicry cross reaction reaction in Diabetes as well as RA which I already knew about.
So what they are saying is that the BCG vaccine is inducing a tolerant immune response to the TB bacteria - and in doing so is changing the auto immune response to self (pancreas cells)
Then I found this - so BCG induces a low inflammatory response to other pathogens -
It would not be too far fetched to suggest a couple of things - just a prediction
1) That a BCG booster might work in other diseases including RA
2) That the original cause in SOME auto-immunity may have been the original childhood BCG given the injection when their immune systems were depressed - for example TNF blockers in RA are suggested to be a no-no for BCG boosting
This study looks at how TB is present in most people - and higher in RA and that anti-TNF often drug treatment reactivates infection - so explains why people with RA don't often get a BCG jab