Subject: Re: What are Citrullinated Proteins?
Hi Julie / Colin I'm quite sure that food allergens in arthritis will be grouped by shared proteins in the foods - lots of vegetables and fruits contain similar proteins. For example all these foods are grouped by a shared allergen - noted apples and lettuce in this list - if your allergic to one then you are more likely (but not definitely) to be allergic to these other ones. (A: Peach; B: Apple; C: Cherry; D: Apricot; E: Plum; F: Pear; G: Strawberry; H: Almond; I: Walnut; J: Hazelnut; K: Peanut; L: Maize; M: Rice; N: Lettuce; O: Kiwi; P: Tomato; Q: Lentil; R: Saffron; S: Melon; T: Pistachio; U: Onion; V: Rucola; W: Cashew; X: Pineapple; Y: Fennel;Z: Other nuts (Brazil nut, coconut, macadamia nut); OF: Other Foods (Bell pepper) ) http://www.eurannallergyimm.com/cont/journals-articles/315/volume-patients-with-syndrome-foodspecific-show-844allasp1.pdf I had a theory that the treatment of Apple juice makes it less likely to trigger an immune response - and found this - https://lirias.kuleuven.be/bitstream/123456789/320931/1/online+version.pdf (Conclusion: The conclusion to be drawn from these results is that the combination of HP and thermal processing is an effective method to reduce the allergenicity of both apple and celeriac.) It's all about proteins - and whether they are left in a state that contain appropriate amino acid sequences (following citrullination) to cross react with our own tissues and mimic other proteins to which we have antibodies to. BTW carrots are more allergic when raw. Depending on the food heating it up can make it either more or less of a potential allergen. For example normal milk is apparently more allergic and inflammatory when pasteurised due to a protein modification - unless you use A2 milk from Guernsey cows - Some farmers are breeding cows that only produce A2 milk as A1 milk is strongly implicated in type 1 autoimmune diabetes - and autism. The EU did a study and decided that there was not enough evidence to cause upheaval to the milk industry. But there's definitely smoke, and lots of little fires burning on this - I give it 5 to 10 years. Article about A2 milk.... http://www.ncbi.nlm.nih.gov/pubmed/17666771 "Milk has been known to cause arthritis in studies....(symptomatic exacerbation of inflammatory arthritis with immunologic hypersensitivity to milk in this patient. This observation suggests new insights in the pathogenesis of inflammatory joint disease and its therapeutic control.!!)" http://onlinelibrary.wiley.com/doi/10.1002/art.1780290210/abstract Good to see the website back! ☺️ Sean
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