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Date: 25.03.2015
From: Rachel

Subject: Does MTX stop working after a while

I have RA and been on 15mg MTX for past 5 years. They upped the dose to 17.5mg 6 months ago but it made no difference. They also added 400mg plaquenil around 5 months ago but didn't help much. Throbbing feet are the main problem - Rheumy says its mechanical rather than inflammation. Very stiff all the time now and just wondered whether a change in meds would make a difference. Rheumy team say nothing more they can do.
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Date: 25.03.2015
From: Paula -R

Subject: Re: Does MTX stop working after a while

Of course there is more that they can do. You have failed on two DMARDS so the next step (that is if you are in the UK) is Anti tnf's.

Please ask about this to see if you meet the criteria with your DAS score. I failed on two drugs, was put on Enbrel November 2012 and was in remission twelve weeks later and still am. Totally changed my life.

Good Luck x
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Date: 25.03.2015
From: Rachel

Subject: Re: Does MTX stop working after a while

Cheers Paula. I will suggest the Anti tnf's when I try and get another appointment.

That's great to hear it changed your life and there is hope.
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Date: 25.03.2015
From: Colin W

Subject: Re: Does MTX stop working after a while

hi Rachel , what is your blood results for CRP & ESR , they may try another drug like Sulpha before they try a anti-tnt , look up das28 score , you need a result over 5 to get the anti-tnt drugs
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Date: 26.03.2015
From: Rachel

Subject: Re: Does MTX stop working after a while

Hi Colin

I will call the Rheumy nurse and try and get the results. They didn't tell me at the appointment. I presume it might not be over 5 if they did not offer me anything else though.

Cheers for your help.
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Date: 26.03.2015
From: lucy

Subject: Re: Does MTX stop working after a while

Hi Rachel, They can add sulphasalazine to the mtx and plaquenil. A lot of people take all three drugs. I take all three and also a biologic drug called rituximab.

Good luck x
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