Subject: Re: methotrexate
Like you I had a significantly raised liver reaction to hydroxychloroquine which was the first drug I was given. Came off it and my liver returned to normal in a couple of months. Been on mtx for over a year now but not totally successful and am waiting to start cimzia, an anti tnf. I think we all have our concerns about what these drugs could do but I came to the conclusion that I had no alternative but to suck it and see. At the end of the day do you live with the long term destruction that the RA could cause if untreated or do you take your chances.
As Rhona says you will be given regular blood tests so they should be able to detect any problems relatively early. And you have to have tried two DMARDs before they will consider you for anything else.
I did however insist that I saw an improvement in my liver before I started on the mtx. It just seemed the most logical thing to do.
Hope this helps.