Subject: Re: Is RA hereditary
RA and especially the severity is linked to certain genetic factors with HLA-DR being a prerequisite for most. HLA-DR has a binding site that expresses an amino acid "motif" of QKRAA. Many gram-negative bacteria including Proteus Mirabilis and E-Coli (and the Epstein Barr virus) contain this QKRAA - expressed in food proteins / dietry lectins including a "genetically modified" bacteria used in the dairy industry - http://en.wikipedia.org/wiki/Lactococcus_lactis http://thepaleodiet.com/wp-content/uploads/2012/04/Modulationofimmunefunctionbydietarylectinsinrheumatoidarthritisabstract1.pdf Role of QKRAA and involvement of E-Coli - http://www.ncbi.nlm.nih.gov/pubmed/9109425 Role of QKRAA and Molecular Mimicry of Proteus Mirabilis - http://www.kickas.org/medical/radocs/S1740252206000059.pdf The link to bacteria and diet is then compelling when we realise that WGA (Wheat Germ Agglutinin) binds to fragments of bacteria cell wall ( N-Acetyl-glucosamine) - WGA then acts as an adjuvant in that it presents the bacteria to the immune system - cross reaction with QKRAA then occurs with T Cell then B Cell involvement - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783150/ The role of Wheat Germ as an anti-nutrient - http://www.ncbi.nlm.nih.gov/pubmed/8399111 BTW - N-acetyl-glucosamine is also present in the supplement form - Glucosamine - and there have been studies that show that the reason glucosamine helps some people is that is binds to the lectins like before the lectins bind to the bacteria. Full loop to my own treatment 30 years agoo uncovered this - a doctor that used to work with my earlier Dr. John Mansfield http://www.salfordallergyclinic.com/sc-lectingroup.html
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