Subject: Re: Is RA hereditary

Hi Laura
My mum had RA and I have it. My two sisters don't n my daughter hasn't tested positive for it so far in her life - she is same age as you.
So although they say it can be heredity it doesn't always mean it will be.
Not an answer for you really but our family history of it
Have you discussed possibility of starting family with docs? Might be a good start to ease your mind or help you decide what you'd like to do.
Hope you are keeping well
Xxx

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Subject: Re: Is RA hereditary

Hi Laura, my mother had severe OA, starting in her 50s. I've got a mixture of inflammatory arthritis and OA but none of my 3 sisters have any sign of it yet. Apparently, I had a great aunt with RA and some relatives with autoimmune illnesses but there is no proven link, as you have read.

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Subject: Re: Is RA hereditary

hi laura
yeah the meds stoppage is a definite i would imagine.
as marlene says there a quite a few young mums on here that could perhaps share their experiences with you
hope you are well today x

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Subject: Re: Is RA hereditary

Thanks all for your replies. I'm due to see my Dr soon so I'll try and talk more in depth about it with him.

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Subject: Re: Is RA hereditary

Hi Laura, My mother had ra and I have ra although I had 2 brothers and a sister that don't have it. As I have 3 daughters it does worry me that they could one day get it but I hope not. One of my daughters has type 1 diabetes which is also an auto-immune disease. I was told it is not hereditary but if there is a genetic link then it increases the risk although they say it takes something to trigger it even with a genetic link.

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Subject: Re: Is RA hereditary

RA and especially the severity is linked to certain genetic factors with HLA-DR being a prerequisite for most.

HLA-DR has a binding site that expresses an amino acid "motif" of QKRAA.

Many gram-negative bacteria including Proteus Mirabilis and E-Coli (and the Epstein Barr virus) contain this

QKRAA - expressed in food proteins / dietry lectins including a "genetically modified" bacteria used in the dairy industry - http://en.wikipedia.org/wiki/Lactococcus_lactis

http://thepaleodiet.com/wp-content/uploads/2012/04/Modulationofimmunefunctionbydietarylectinsinrheumatoidarthritisabstract1.pdf

Role of QKRAA and involvement of E-Coli -

http://www.ncbi.nlm.nih.gov/pubmed/9109425

Role of QKRAA and Molecular Mimicry of Proteus Mirabilis -

http://www.kickas.org/medical/radocs/S1740252206000059.pdf

The link to bacteria and diet is then compelling when we realise that WGA (Wheat Germ Agglutinin) binds to fragments of bacteria cell wall ( N-Acetyl-glucosamine) - WGA then acts as an adjuvant in that it presents the bacteria to the immune system - cross reaction with QKRAA then occurs with T Cell then B Cell involvement -

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783150/

The role of Wheat Germ as an anti-nutrient -
http://www.ncbi.nlm.nih.gov/pubmed/8399111

BTW - N-acetyl-glucosamine is also present in the supplement form - Glucosamine - and there have been studies that show that the reason glucosamine helps some people is that is binds to the lectins like before the lectins bind to the bacteria.

Full loop to my own treatment 30 years agoo uncovered this - a doctor that used to work with my earlier Dr. John Mansfield

http://www.salfordallergyclinic.com/sc-lectingroup.html

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