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Date: 26.04.2012
From: Sarah

Subject: Swollen neck lymph nodes on Sulfasalazine

Hi Everyone,
This is my first post on this forum. I was diagnosed with PsA 2 years ago. It has progressed quite aggressivley to the extent that I've had to give up work. My Rheumatologist started me on Sulfasalazine 1,000mg per day for the 1st week and then 2,000mg on the second week. By day 11 I developed very painful swollen neck lymph nodes and shivers followed by night sweats. The Rheumatologist stopped the Sulfa when I saw him on day 14 for my bloods. The shivers and night sweats have stopped but I still have the really painful neck lymph nodes. The Rheumatologists thinks I just have a viral infection but I have no other symptoms. Has anyone else experienced the painful neck lymph nodes whilst on Sulfa?
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Date: 26.04.2012
From: Mike

Subject: Re: Swollen neck lymph nodes on Sulfasalazine

Hi Sarah,

I experienced exactly the same thing. I was on my third week of taking sulfasalazine and my lymph nodes became very swollen and very tender. I went to my GP who said I had laryngitis and also tonsillitis and gave my penicillin. My rheumatologist told me to stop taking the sulfa until I had finished the penicillin.
The infection cleared up in about 6 days And my lymph nodes returned to normal size.

I did start taking the sulfa again but suffered from Photosensitivity and also extremely bad itching all over my body.
So my rheumy told me to stop taking sulfa and I am going to be taking methotrexate starting on 7.5mg weekly. I am also a PaS sufferer.
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Date: 26.04.2012
From: Sarah

Subject: Re: Swollen neck lymph nodes on Sulfasalazine

Hi Mike
Thank you for such a quick response. I'm so sorry to hear about your suffering with Sulfa. I'm hoping the lymph nodes will settle down now that I'm of it. My Rheum has put me back onto Arcoxia although now it's 90mg instead of the 60mg that I've been on for the past 2 years.
Have you started on the MTX yet? What's been your experience?
My Rheum mentioned MTX to me but I just find all these drugs so scary. I was on predisolone for a year whilst on Arcoxia but I weaned myself of it at Xmas as I got so fed up with all the weight gain and I just didnt feel like it was doing anything!
In fact today I didn't even take the Arcoxia as I just wanted a drug free day! I'm going to start back at the gym (& Arcoxia) tomorrow as I find I cope better with the pain when I'm more
active.
How are you coping with your PsA? All the nails on my hands are psoriatic, I have minor patches of psoriasis on my body although most is on my scalp. I was ticking along quite nicely until I got the arthritis part 2 years ago which is now in 1 knee, both hips & shoulder joints, top half of my spine, fingers in both hands & a couple of toes on one foot! So no wonder it hurts to move (or even not move)!
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